Enhanced Na+Channel Intermediate Inactivation in Brugada Syndrome
نویسندگان
چکیده
منابع مشابه
Enhanced Na(+) channel intermediate inactivation in Brugada syndrome.
Brugada syndrome is an inherited cardiac disease that causes sudden death related to idiopathic ventricular fibrillation in a structurally normal heart. The disease is characterized by ST-segment elevation in the right precordial ECG leads and is frequently accompanied by an apparent right bundle-branch block. The biophysical properties of the SCN5A mutation T1620M associated with Brugada syndr...
متن کاملBrugada syndrome.
Brugada syndrome is a rare cardiac arrhythmia characterized by electrocardiographic right bundle branch block and persistent ST-segment elevation in the right precordial leads. It is associated with ventricular fibrillation and a high risk for sudden cardiac death, predominantly in younger males with structurally normal hearts. Patients can remain asymptomatic, and electrocardiographic patterns...
متن کاملBrugada syndrome.
First introduced as a new clinical entity in 1992, the Brugada syndrome is associated with a relatively high risk of sudden death in young adults, and occasionally in children and infants. Recent years have witnessed a striking proliferation of papers dealing with the clinical and basic aspects of the disease. Characterized by a coved-type ST-segment elevation in the right precordial leads of t...
متن کامل[Brugada syndrome].
The Brugada syndrome is characterised clinically by the occurrence of syncope or sudden death due to ventricular arrhythmias in patients with structurally normal hearts and electrocardiographic signs of right bundle branch block and ST elevation in the right precordial leads (V1 to V3). The transmission of the condition is autosomal dominant with variable penetration. Mutations have been identi...
متن کاملBrugada Syndrome
Submit Manuscript | http://medcraveonline.com in 1992 by the Brugada brothers [1,2]. In 1992 it has originally been described as an autosomal-dominant inherited arrhythmic disorder defined by ST elevation with successive negative T wave without structural cardiac abnormalities in the right precordial leads [3]. In 1996, in the description of the cellular basis for the J-wave of the ECG by Yan a...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2000
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.87.8.e37